Open AccessCongenital anomalies in newborns of women with type 1 diabetes: nationwide population‐based study in Norway, 1999–2004
Author(s) -
Eidem Ingvild,
Stene Lars C.,
Henriksen Tore,
Hanssen Kristian F.,
Vangen Siri,
Vollset Stein E.,
Joner Geir
Publication year - 2010
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349.2010.518594
Subject(s) - medicine , type 2 diabetes , pediatrics , population , diabetes mellitus , obstetrics , type 1 diabetes , endocrinology , environmental health
Objective . To estimate the risk of congenital anomalies in offspring of women with type 1 diabetes in Norway during recent years. Design . Nationwide population‐based study using the Medical Birth Registry of Norway and the Norwegian type 1 Diabetes Registry. Setting . All birth clinics in Norway. Participants . All births in Norway during 1999–2004 ( N = 350,961), of which 1,583 were births by a mother registered with pregestational type 1 diabetes. Main outcome measure . Congenital anomalies, excluding minor anomalies according to the EUROCAT system. Results . Anomalies were registered in 5.7% of offspring of women with type 1 diabetes, and in 2.9% among the background population (odds ratio 2.1, 95% CI: 1.7–2.6). Cardiovascular anomalies were registered in 3.2% in the diabetes group and 0.94% in the background population (odds ratio 3.5, 95% CI: 2.7–4.7). Results were similar when restricted to women identified with type 1 diabetes through the Diabetes Registry. Conclusions . Women in Norway with type 1 diabetes experience a significantly higher risk of congenital anomalies in their babies compared with the background population.