Open AccessPeripartum serum leptin and soluble leptin receptor levels in women with gestational diabetes
Author(s) -
Chen Danqing,
Xia Guiyu,
Xu Ping,
Dong Minyue
Publication year - 2010
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349.2010.514040
Subject(s) - medicine , leptin , gestational diabetes , endocrinology , diabetes mellitus , pregnancy , leptin receptor , receptor , gestation , obstetrics , obesity , biology , genetics
The purpose of the study was to clarify the alterations in serum leptin and soluble leptin receptor levels at term and early postpartum in gestational diabetes mellitus (GDM). Twenty women with normal pregnancy and 20 with GDM were recruited and blood samples were taken on the day of delivery and Days 1, 3 and 5 after delivery. Serum leptin levels were significantly higher in women with GDM than in the controls before delivery and decreased significantly after delivery ( p < 0.001). After delivery there were no significant differences in serum leptin concentrations between women with GDM and the controls. Serum soluble leptin receptor concentrations did not differ neither between the two groups, nor before or after delivery. Leptin may play a role in GDM through a positive correlation with insulin resistance.