Open AccessLow maternal PAPP‐A is associated with small‐for‐gestational age newborns and stillbirths
Author(s) -
Marttala Jaana,
Peuhkurinen Sini,
Laitinen Paivi,
Gissler Mika,
Nieminen Pentti,
Ryynanen Markku
Publication year - 2010
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349.2010.493195
Subject(s) - medicine , obstetrics , small for gestational age , gestational age , pregnancy , biology , genetics
We investigated the association of first trimester low maternal serum pregnancy‐associated plasma protein‐A (PAPP‐A) levels with small‐for‐gestational age (SGA) newborns and stillbirths (SBs) in a retrospective national population‐based register study. The study group comprised 921 women with the lowest 5% PAPP‐A levels (≤0.3 MoM) and the control group comprising 18,615 women with PAPP‐A levels >0.3 MoM. In the study group there were 35 (3.8%) and in the control group 213 SGA newborns (1.1%), respectively (OR, 3.41; 95% CI, 2.37–4.91). There were 9 (1.0%) and 51 (0.3%) cases of SBs in the study and control groups, respectively ( p < 0.002; OR, 3.59; 95% CI, 1.76–7.32). Low PAPP‐A is a risk factor for SGA and SB.