Intravenous Infusion Of 15 Methyl‐Prostaglandin F 2α (Prostinfenem®) In Women With Heavy Post‐Partum Hemorrhage

Post‐partum hemorrhage is a serious complication in obstetric practice. The aim of this study was to investigate, in vivo, the effects of 15 methyl‐prostaglandin F 2α (Prostinfenem®, Upjohn, Sweden) on uterine activity and hemorrhage. Twenty‐seven women were included in the study and, in accordance with our clinical routine, all were given oxytocin (10 IE Syntocinon®) intramuscularly immediately after delivery. In cases of heavy bleeding and signs of uterine atony, ethylergometrine (0.2 mg Methergin®) and oxytocin (40 i. e. Syntocinon® in 500 ml, 5.5% glucose) were administered intravenously. If this therapy failed, the woman was given an intravenous infusion of 15‐methyl‐prostaglandin F 2α (0.25 mg Prostinfenom®, in 500 ml, 5.5% glucose). Myometrial activity was quantitated in 5 women by a micro‐transducer introduced into the uterine cavity. The treatment resulted in a contracted uterus and cessation of bleeding within 12.5 min (mean). The intra‐uterine pressure registered a prompt effect regarding both amplitude and frequency of uterine contractions.