Open AccessDNA ploidy and steroid receptors as predictors of disease course in patients with endometrial carcinoma
Author(s) -
Iversen Ole E.,
Utaaker Edle,
Skaarland Elsa
Publication year - 1988
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348809029865
Subject(s) - ploidy , medicine , receptor , carcinoma , oncology , endometrial cancer , stage (stratigraphy) , multivariate analysis , prospective cohort study , progesterone receptor , pathology , disease , gynecology , cancer , biology , estrogen receptor , breast cancer , gene , genetics , paleontology
Prognostic factors for outcome of malignant disease should be based on objective assessments whenever possible, so that the results may be reproduced. In a prospective study, tumor samples from 75 patients were subjected to flow cytometric DNA analysis. Samples were also taken from 61 patients for estradiol and progesterone receptor measurements. The course of the disease was analysed with regard to ploidy and receptor status. Receptor status was significantly correlated with ploidy, as diploid tumors were more often receptor‐positive or receptor‐rich (≥30 fmo/mg protein). Mortality and recurrence rates were highest among patients with aneuploid or receptor‐poor tumors. Ploidy, receptor status, histological grade, surgical stage, and myometrial invasion were found to be of significant prognostic value. By multivariate analysis, ploidy was indicated to be the best predictor, followed by surgical stage. DNA and receptor measurements are recommended in research on endometrial carcinoma, and may become useful in routine clinical work.