Open AccessMulticenter Trial of a Monophasic Oral Contraceptive Containing Ethinyl Estradiol and Desogestrel
Author(s) -
Rekers Hans
Publication year - 1988
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348809004193
Subject(s) - desogestrel , medicine , ethinylestradiol , incidence (geometry) , gynecology , pregnancy , obstetrics , multicenter trial , family planning , population , randomized controlled trial , research methodology , multicenter study , physics , environmental health , biology , optics , genetics
. A clinical trial was conducted at 47 centers in 11 countries to assess the efficacy and acceptability of a monophasic oral contraceptive containing 30 g ethinyl estradiol and 150 g desogestrel. 1,613 women took part for a total of 23,258 cycles. One pregnancy occurred in a cycle where two consecutive tablets had been forgotten. Cycle control was excellent, with reported decreases in the duration and amount of withdrawal bleeding during consecutive treatment cycles and a low incidence of irregular bleeding. Blood pressure was not affected during 2 years of use. The incidence of minor side effects was already low in the first treatment cycle and decreased further in the subsequent cycles. The combination (Marvelon) was shown to be a very reliable and acceptable oral contraceptive.