Open AccessCalcitonin Secretion by Human Placental Tissue
Author(s) -
Balabanova S.,
Kruse B.,
Wolf A. S.
Publication year - 1987
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348709103646
Subject(s) - calcitonin , secretion , placenta , medicine , in vitro , antibody , radioimmunoassay , human placenta , endocrinology , immunoassay , tissue culture , fetus , pregnancy , biology , immunology , biochemistry , genetics
We have investigated the synthesis in vitro of calcitonin (CT) by human placenta at. term. Separate placental tissue samples were incubated in culture medium with various Ca concentrations for 6 h. The CT concentrations in the medium were determined by radio‐immunoassay. In addition the effect of DB‐cAMP on the synthesis was also studied. We could demonstrate CT secretion in all experiments. The CT concentrations were determined by two different antibodies. Both antibodies registered the CT secretion. Addition of DB‐cAMP to the culture medium stimulates the synthesis.