Open AccessPreinduction Cervical Softening with Endocervical Pge 2 Gel: A multi‐center trial
Author(s) -
Noah M. L.,
Decoster J. M.,
Fraser T. J.,
Orr J. D.
Publication year - 1987
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348709092944
Subject(s) - medicine , oxytocin , induction of labor , randomized controlled trial , bishop score , prospective cohort study , anesthesia , labor induction , pregnancy , cervix , surgery , gynecology , genetics , cancer , biology
In a prospective, randomized trial, a single dose of PGE 2 gel, 0.5 mg (2.5 ml), was given to 416 low Bishop Score patients 12 h prior to indicated oxytocin induction and compared with 404 non‐gel controls. Successful initial induction was achieved in 83% of the treated and 58% of the non‐treated subjects. In addition the induction—delivery interval was shortened (median times 9.0 h vs. 11.3 h) and fewer cesarean sections were performed (16% vs. 21%) in the PGE 2 gel series. The endocervical administration of PGE 2 was well tolerated and, provided care is taken to avoid excess extra‐amniotic placement, systemic PGE 2 effects are minimal.