Open AccessSerum Estrogen Levels After Topic Application of Estradiol‐17β on two Different Cutaneous Areas
Author(s) -
Hoist Juhani,
Carlström Kjell,
Schoultz Bo
Publication year - 1987
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348709083037
Subject(s) - medicine , estrone , estrogen , estrogen therapy , abdomen , ethinylestradiol , percutaneous , thigh , endocrinology , surgery , research methodology , population , environmental health
Circulating estrogen concentrations were compared in 11 postmenopausal women during 3 months of percutaneous administration of estradiol‐17β on the skin of the abdomen and on the thigh. The absorption from the the two different cutaneous areas was equally effective and the serum levels of estradiol‐17β were in the same range as previously reported after oral therapy with doses of 2 mg est‐radiol. In contrast to oral therapy the excessive conversion into estrone was avoided. The medial inner aspect of the thigh could be used as an alternative to abdominal application during percutaneous estrogen therapy.