Open AccessOxytocin‐ or Low‐Dose Prostaglandin F 2α ‐Infusion for Stimulation of Labor After Primary Rupture of Membranes: A prospective, randomized trial
Author(s) -
Møller M.,
Thomsen A. C.,
Sørensen J.,
Forman A.
Publication year - 1987
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348709083028
Subject(s) - medicine , oxytocin , prom , bishop score , randomized controlled trial , prostaglandin , prospective cohort study , gestation , stimulation , randomization , rupture of membranes , pregnancy , anesthesia , obstetrics , gynecology , surgery , cervix , cancer , biology , genetics
One hundred consecutive women with singleton pregnancies and primary rupture of membranes (PROM) after 36 weeks of gestation were included in a prospective, randomized trial of intravenous infusion of oxytocin (up to 30 mIU/min) versus low‐dose prostaglandin F 2α (PGF 2α up to 6.0 μg/min). Cesarean section was performed in 12 patients because of suspected disproportion or intra‐uterine asphyxia. Effective contractions or labor progress failed to become established within 8 hours in another 4 women stimulated with PGF 2α and 2 stimulated by oxytocin. The stimulation delivery time (hours) for the remaining 82 women treated with PGF 2α or oxytocin, respectively was 8.7 against 12.1 for initial Bishop score <5 (p<0.01), (Mann‐Whitney test), 7.2 vs. 7.1 for Bishop score 5–8 and 5.7 vs. 4.2 for Bishop score >8. Patients with initial Bishop score <5 seemed to need analgetics less often when treated with PGF 2α than with oxytocin. Frequencies of side effects and instrumental deliveries as well as the fetal outcome were similar for the two treatment schedules. The results of the study suggest that low‐dose PGF 2α infusion may be the more appropriate treatment for women with an unfavorable initial Bishop score.