Open AccessAmniotic immunoreactive trypsin in pregnancies with normal and pathological outcomes
Author(s) -
Laroche Dominique,
Herlicoviez Michel,
Pasquet Catherine,
Travert Georges,
Fernandez Yvon
Publication year - 1987
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348709022061
Subject(s) - medicine , amniotic fluid , cystic fibrosis , fetus , meconium , pathological , gestational age , polyhydramnios , obstetrics , pregnancy , alkaline phosphatase , gastroenterology , endocrinology , enzyme , biology , biochemistry , genetics
Immunoreactive trypsin (IRT) has been studied in amniotic fluid as a possible complementary test substance for the prenatal diagnosis of cystic fibrosis (CF). 219 normal amniotic fluids have been tested in order to establish the normal ranges from 14 to 40 gestational weeks (g.w.). The IRT level increases from g.w. 14 to 19, remains stable from g.w. 19 to 25 and then decreases rapidly to low levels. A retrospective study of 4 presumed CF fluids, as determined by abnormal alkaline phosphatase levels, showed decreased IRT values in 3 out of 4 fluids. The difference between the mean value and the normal mean was not significant. The prospective study allowed us to test 2 fluids from pregnancies affected by meconium ileus. IRT level was highly elevated, 530 times the normal mean value at g.w. 34 for a non‐CF fetus and 18 times the normal mean value for a CF fetus at g.w. 31. In 4 out of 5 cases of fetal severe intra‐uterine growth retardation, IRT levels appeared mildly elevated. Other abnormalities are reviewed.