Open AccessCerebral metastases from choriocarcinoma
Author(s) -
Sen D. K.,
Sivanesaratnam V.,
Chuah C. Y.,
Ch'ng S. L.,
Singh J.,
Paramsothy M.
Publication year - 1987
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348709022047
Subject(s) - medicine , choriocarcinoma , chemotherapy , methotrexate , radiation therapy , kuala lumpur , lung , toxicity , surgery , oncology , marketing , business
Of 36 cases of choriocarcinoma treated at the University Hospital Kuala Lumpur during 1980‐84 inclusive, 6 patients were found to have cerebral metastases. Intrathecal methotrexate and combination chemotherapy were started in all cases, with monitoring of tumor growth by serial β‐HCG assays and CT scanning of brain and lung. Chemotherapy was reduced because of severe toxicity in 2 patients, one of whom received radiotherapy to the brain. Four patients (66%) have now been in remission for 2.5–6 years. Two did not respond to therapy and died. The factors involved in therapy and response are discussed.