Open AccessThe Effect of Pregnancy on Functions of Inflammatory Cells in Healthy Women and in Patients with Rheumatic Disease
Author(s) -
Østensen Monika,
Revhaug Arthur,
Volden Gunnar,
Berge Lillian,
Husby Gunnar,
Giercksky KarlErik
Publication year - 1987
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348709020757
Subject(s) - medicine , phagocytosis , pregnancy , gestation , zymosan , extracellular , intracellular , enzyme , immunology , endocrinology , peripheral blood mononuclear cell , andrology , biochemistry , biology , in vitro , genetics
Chemiluminesence (CL) after zymosan stimulated phagocytosis of polymorphonuclear granulocytes (PMN) and mononuclear cells (MNC), random migration of PMN and intra‐and extracellular activities of nine lysosomal enzymes were assessed serially in 8 healthy women and 10 women with rheumatic disease during and after pregnancy. A gestational increase of lysosomal enzymes in serum and enhancement of PMN random migration was observed in all women. Significant differences between healthy and rheumatic women were found for CL of phagocytic cells. In healthy women, CL of PMN was slightlv enhanced, while it remained unchanged in MNC during pregnancy. In patients, CL of PMN was markedly suppressed, while MNC CL increased during gestation. An inverse relationship between CL and intracellular enzyme activities was noted. Thus, the presence of an inflammatory state seemed to influence the gestational behavior of phagocytic cells.