Open AccessEvidence of an Estrogen‐Like Effect of Dehydroepiandrosterone On Lysyl Oxidase Activity in the Mouse Cervix
Author(s) -
Ozasa Hiroshi,
Tominaga Toshiro,
Takeda Toshio
Publication year - 1986
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348609158383
Subject(s) - lysyl oxidase , endocrinology , dehydroepiandrosterone , ovariectomized rat , medicine , estrogen , cervix , enzyme assay , enzyme , steroid , hormone , biology , biochemistry , androgen , cancer
The effect of dehydroepiandrosterone (DHA) on the lysyl oxidase activity in the mouse cervix was studied. Injection of animals ovariectomized 10 days before with 1 mg DHA was followed 24 h later by an increase in enzyme activity, which remained unaltered for 48 h, returning to control values by 96 h after injection. At least 100 μg of DHA was required to increase enzyme activity; the maximum effect occurred with 1 mg of the steroid and was comparable to that of 1 μg estradiol‐17β. These results demonstrate an estrogen‐like effect of DHA on lysyl oxidase activity in mouse cervix. the onset of response was later and the duration of response was longer for DHA than for estradiol‐17β.