Open AccessFibrinolytic Activity in Amniotic Fluid During Late Pregnancy
Author(s) -
Pschera H.,
Kjaeldgaard A.,
Larsson B.
Publication year - 1986
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348609157375
Subject(s) - amniotic fluid , amniocentesis , medicine , gestation , andrology , fetus , gestational age , pregnancy , amniotic fluid embolism , obstetrics , fibrin , gynecology , prenatal diagnosis , immunology , biology , genetics
Fibrinolytic activity (FA) was assessed by the fibrin plate technique in 47 amniotic fluid samples obtained at 35 to 39 weeks' gestation. in amniotic fluid the FA (63.1±2.5 mm 2 ) was considerably elevated when compared with previously reported serum levels of pregnant women. After centrifugation of the amniotic fluid samples a highly significant reduction of FA in the supernatant was recorded (42.9±1.3 mm 2 ), suggesting that the cells of fetal origin are the main source of the high plasminogen activator activity demonstrated in amniotic fluid. a significant rise in amniotic fluid FA was demonstrated beyond the 37th gestational week. Furthermore, significantly greater FA was recorded in amniotic fluid samples from women with spontaneous onset of labor within a week. However, a single FA determination in amniotic fluid obtained by routine amniocentesis was found to be of little value for prediction of the time interval to delivery.