Open Accessα‐Methyldopa For Climacteric Hot Flushes: A Double‐Blind, Randomized, Cross‐Over Study
Author(s) -
Andersen O.,
Engebretsen T.,
Solberg V. M.,
Ørbo A.
Publication year - 1986
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348609157373
Subject(s) - climacteric , medicine , evening , placebo , methyldopa , randomized controlled trial , dose , regimen , double blind , gynecology , menopause , blood pressure , physics , alternative medicine , pathology , astronomy
The effects of single evening doses of α‐methyldopa and placebo have been compared in 40 women with climacteric hot flushes. the study was designed as a double‐blind, randomized and cross‐over investigation. of the 24 patients who completed the study, 15 reported that they preferred the α‐methyldopa treatment (p<0.05). α‐methyl‐dopa seemed to affect both the severity (p<0.05) and the frequency of climacteric hot flushes (p>0.05). It is concluded that α‐methyldopa is efficacious against climacteric hot flushes when given as single evening doses, but further study is required to answer whether this dosage is as effective as a twice daily regimen.