Open AccessNO EFFECT OF VITAMIN B‐6 AGAINST PREMENSTRUAL TENSION
Author(s) -
Hagen Inger,
Nesheim Brittingjerd,
Tuntland Tove
Publication year - 1985
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348509158211
Subject(s) - medicine , placebo , premenstrual tension , crossover study , menstrual cycle , menstruation , vitamin , placebo group , magnesium , physiology , endocrinology , hormone , alternative medicine , pathology , materials science , metallurgy
. Vitamin B‐6 100 mg given daily throughout the menstrual cycle was compared with placebo in a randomized, double‐blind crossover trial in 34 women who suffered from premenstrual tension. Vitamin B‐6 was no better than placebo. There was a substantial period effect, as the women evidenced a considerable preference for the second drug they received, irrespective of whether this was vitamin B‐6 or placebo. Blood magnesium was measured; no significant difference was found between the 34 women with premenstrual tension and 10 healthy women without such complaints. Vitamin B‐6 caused a small but statistically significant rise in blood magnesium level. In the individual patients, no correlation was found between changes in blood magnesium and premenstrual symptoms.