Open AccessLACK OF EFFECT OF ARBAPROSTIL ON THE HUMAN NON‐PREGNANT UTERUS
Author(s) -
Reele S. B.,
Euler A. R.,
Hanover C. K.,
Lookabaugh J. L.
Publication year - 1985
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348509158206
Subject(s) - medicine , uterus , menstrual cycle , prostaglandin , gynecology , obstetrics , physiology , hormone
. Arbaprostil ((15R)‐15‐methyl Prostaglandin E 2 ) is being studied for the treatment of gastrointestinal illness. To determine its effect on the human uterus, eight sterilized pre‐menopausal women were studied during the proliferative phase of their menstrual cycle. Using a microtransducer catheter, intra‐uterine pressures were recorded for at least 30 minutes prior to and 2 hours after arbaprostil administration. Each subject was studied four times, at 48‐hour intervals, receiving in a double‐blind manner; 0,10, 25, and 50 μg. Arbaprostil at doses up to 50 μg was found not to have any clinically significant effects on the non‐pregnant human uterus.