Open AccessPLASMA 20α‐OH‐PROGESTERONE IN WOMEN WITH MALIGNANT EPITHELIAL ‘NON‐ENDOCRINE’ OVARIAN TUMORS
Author(s) -
Mählck CarlGustav,
Bäckström Torbjörn,
Kjellgren Olle,
Selstam Gunnar
Publication year - 1985
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348509156731
Subject(s) - medicine , palpation , ovarian cancer , ovary , carcinoma , endocrine system , gynecology , hormone , postmenopausal women , cancer , endocrinology , urology , surgery
. the production of 20α‐OH‐progesterone (20α‐OH‐P) in women with malignant epithelial ovarian tumors was investigated. the study material comprised 51 postmenopausal and/or oophorectomized women with ovarian carcinoma, including the histological types Ic, IIc, IIIc and V and F1GO stages I‐IV. Their tumor volumes were evaluated once a month using bimanual recto‐vaginal palpation under anesthesia. Blood samples were drawn for 20α‐OH‐P radio‐immunoassay at monthly intervals for 3 months. the plasma levels were compared with those of a control group of postmenopausal women. the results show a relationship between tumor volume and plasma 20α‐OH‐P level. Another finding is that endometrioid ovarian cancer (histologically IIIc) showed a significantly lower 20α‐OH‐P production than the other types. the reason for this is discussed.