Open AccessA PROSPECTIVE CONTROLLED TRIAL OF METOPROLOL‐HYDRALAZINE TREATMENT IN HYPERTENSION DURING PREGNANCY
Author(s) -
Högstedt Stellan,
Lindeberg Solveig,
Axelsson Ove,
Lindmark Gunilla,
Rane Anders,
Sandström Bo,
Lindberg Bo S.
Publication year - 1985
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348509156729
Subject(s) - medicine , hydralazine , pregnancy , blood pressure , metoprolol , apgar score , hypoglycemia , respiratory distress , labetalol , obstetrics , fetal distress , bradycardia , randomized controlled trial , hypertension in pregnancy , anesthesia , birth weight , fetus , surgery , diabetes mellitus , preeclampsia , heart rate , endocrinology , genetics , biology
. in an open, controlled trial, treatment with a combination of metoprolol and hydralazine was compared with non‐pharmacological management of mild and moderate hypertension in pregnancy. One hundred and sixty‐one women participated in the study. the drug‐treated group showed significantly better blood pressure control than the group not given antihypertensives. Induction of labor before term, because of maternal or fetal complications, was somewhat more frequent in the control group. Nine women in the treatment group and 5 in the control group developed albuminuria. Three infants in the drug‐treated group died perinatally, and one in the control group. the outcome for the newborns was similar in both groups concerning birth weight, head circumference and Apgar score and in the frequencies of respiratory distress, bradycardia and hypoglycemia. the better blood pressure control achieved with these drugs makes it possible to treat the patient at home and reduce the risk of emergency delivery, but treatment does not seem to be mandatory for a good outcome of the pregnancy in cases of mild and moderate hypertension during pregnancy.