Open AccessEFFECT OF THE NATURALLY OCCURRING PROSTAGLANDINS E 2 AND F 2α ON THE HUMAN MYOMETRIUM IN VIVO DURING PREGNANCY
Author(s) -
Rydnert Jan,
Joelsson Ingemar
Publication year - 1985
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348509156366
Subject(s) - myometrium , in vivo , contractility , medicine , uterine contraction , distension , contraction (grammar) , pregnancy , prostaglandin e , endocrinology , smooth muscle , prostaglandin , in utero , biological activity , uterus , pharmacology , in vitro , fetus , biology , biochemistry , genetics , microbiology and biotechnology
. Hysterometry has been used to evaluate the effect on the human myometrium in vivo during early pregnancy of the naturally occurring prostaglandins E 2 and F 2α . The hystermetric technique is based upon the fact that mechanical distension of smooth muscle induces contraction. According to the analysis of the contractile responses, the effects of the agents have been determined quantitatively. The drug effects have been characterized by changes in myometrial response between registrations under basic conditions and during the infusion of the active agent, respectively. It was found that when these drugs were given in the doses usually employed in clinical practice, the effect on contractility of the PGF 2α compound was more pronounced than that of the PGE 2 . However, when describing the results on a microgram basis, the PGE 2 was confirmed to be more potent than the PGF 2α by a factor of up to 7–8.