Open AccessBROMOCRIPTINE INHIBITION OF HYPERPROLACTINEMIA DURING SURGERY
Author(s) -
Jullien Y.,
Rochette A.,
Desch G.,
Descomps B.,
Cailar J.
Publication year - 1985
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348509155156
Subject(s) - medicine , prolactin , bromocriptine , fentanyl , anesthesia , surgery , hormone
. The material included two groups of 10 women undergoing diagnostic laparoscopy. General anesthesia was administered by injection of 0.1 mg fentanyl followed by infusion of propanidide‐succinylcholine. The control group received no medication prior to surgery, whereas patients in the experimental group were given 5 mg bromocriptine per os. Blood samples for prolactin determinations were drawn as the patients were placed on the operating table and immediately following surgery. The association of anesthesia and surgery caused prolactin levels to rise from 10.9±3.5 to 168+18.7 ng.ml −1 in the control group (p <0.001) and from 3.5±0.5 to 7.5±1.1 ng.ml −1 in the test group (p<0.001). A significant difference was noted between the two groups for their pre‐ and postoperative levels and prolactin response (p<0.05, p<0.001 and p<0.001, respectively). The proposed protocol successfully suppresses prolactin increase during surgery and constitutes a useful tool for investigating hyperprolactinemia and its consequences during this same time. Possible applications include in vitro fertilization and studies on prolactin receptor‐bearing tumors.