Open AccessCOMPARISON OF CELLULAR LEVELS OF STEROID RECEPTORS IN UTERINE LEIOMYOMA AND MYOMETRIUM
Author(s) -
Tamaya T.,
Fujimoto J.,
Okada H.
Publication year - 1985
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348509155136
Subject(s) - myometrium , leiomyoma , estrogen receptor , estrogen , endocrinology , uterus , receptor , cytosol , medicine , uterine leiomyoma , progestin , steroid , hormone , andrology , chemistry , pathology , cancer , enzyme , breast cancer , biochemistry
. To support the estrogen hypothesis in the patho‐genesis of leiomyoma, total cellular estrogen receptor (ER) levels (the sum of levels in cytosol and nuclear KCl‐extract‐able and nuclear non‐KCl‐extractable fractions) were assayed and compared with levels of progestin (PR) and an‐drogen (AR) receptors in the leiomyoma and the corresponding myometrium. The ratios of ER to PR or AR levels were higher (with statistical significance) in leiomyoma than in the corresponding normal myometrium, both in terms of total cellular levels in' each individual case and nuclear levels. It appears that estrogen sensitivity is higher in the leiomyoma than in the corresponding myometrium, due to the relative increasc in ER.