Open AccessA NEW VAGINAL ANTIFUNGAL AGENT – BUTOCONAZOLE NITRATE
Author(s) -
Jacobson Jan B.,
Hajman Aleksander J.,
Wiese JØRgen,
Gandrup Per,
Forsström Sven
Publication year - 1985
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348509155121
Subject(s) - miconazole nitrate , medicine , clotrimazole , miconazole , vaginitis , incidence (geometry) , vulvovaginal candidiasis , antifungal , surgery , dermatology , gynecology , physics , optics
. The continuously increasing incidence of vulvo‐vaginal candidiasis necessitated a search for novel therapeutic modalities. Butoconazole nitrate (BN) a new imida‐zole, has been singled out for clinical studies since, in experimental vaginal candidiasis, it proved more effective than either miconazole nitrate (MN) or clotrimazole. One hundred and thirty volunteers with vaginal candidiasis, verified by wet mount and positive fungal culture, were randomly assigned to receive‐daily, for 6 days, either 1% BN (44 patients), or 2% BN (45 patients) vaginal cream or 2% MN (41 patients) vaginal cream. The patients were comparable regarding age (85% were 18–39 years of age), gravidi‐ty and parity. Twenty‐five per cent had a recent history of unsuccessfully treated fungal vaginitis. Eight days after completion of treatment, negative fungal cultures were found in 98% of the patients using 2% BN, in 91% of patients using 1% BN and in 83% using 2% MN. The recurrence rate of the disease was low; about 80% of patients using 1% and 2% BN and 68% of those using 2% MN were culture‐negative 30 days after conclusion of treatment. Rapid relief of clinical symptoms was experienced by patients in all three treatment groups. No significant side effects of the treatment were observed in any of the treatment groups.