Open AccessPlasma lipoproteins during and after danazol treatment
Author(s) -
Fåhraeus Lars,
LarssonCohn Ulf,
Ljungberg Sten,
Wallentin Lars
Publication year - 1984
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348409157000
Subject(s) - danazol , medicine , cholesterol , lipoprotein , endocrinology , endometriosis , plasma lipoprotein , total cholesterol
. Twelve women with pelvic endometriosis were treated with danazol, at a dose of 200 mg three times daily, over a 24‐week period. The concentrations of cholesterol and triglycerides were determined in plasma and in the lipoprotein fractions. After only 2 weeks the mean high density lipoprotein (HDL) cholesterol had already decreased by 49% and 6 weeks later the reduction was 59%. The low density lipoprotein (LDL) cholesterol concentration increased by 14% after 2 weeks and by 34% after 8 weeks. The triglycerides increased by 20% after 2 weeks. Eight weeks after cessation of treatment the lipoprotein fractions had returned to the pretreatment levels.