Open AccessPeripheral levels of dehydroepiandrosterone sulfate, dehydroepiandrosterone, androstenedione, and testosterone following different doses of danazol
Author(s) -
Carlström Kjell,
Döberl Anton,
Gershagen Sten,
Rannevik Gunnar
Publication year - 1984
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348409156998
Subject(s) - dehydroepiandrosterone sulfate , dehydroepiandrosterone , danazol , androstenedione , testosterone (patch) , endocrinology , medicine , chemistry , androgen , peripheral , hormone , endometriosis
. Peripheral serum levels of dehydroepiandrosterone sulfate (DHAS), dehydroepiandrosterone (DHA), an‐drostenedione (A4) and testosterone (T) were measured in two groups of premenopausal women with fibrocystic breast disease, given 200 and 400 mg of danazol a day respectively for 6 months. During treatment, DHAS levels increased and DHA, DHA/DHAS ratio, A4, and T decreased. A tendency towards dose dependency was observed. The changes in DHAS, DHA and DHA/DHAS ratio were interpreted as resulting from inhibition of liver sulfatase activity by danazol. The decreased A4 and T levels probably reflect a suppression of ovarian steroidogenesis due to enzyme inhibition by danazol, and for the latter steroid also an increased metabolism due to interaction of the drug with sex hormone‐binding globulin.