Open AccessHistochemical localization of specific estrogen and progesterone binding in human endometrium and endometriotic tissue
Author(s) -
Bergqvist Agneta,
Carlström Kjell,
Jeppsson Sten,
Ljungberg Otto
Publication year - 1984
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348409156973
Subject(s) - estrogen , endometrium , progesterone receptor , endometriosis , endocrinology , chemistry , medicine , biology , estrogen receptor , cancer , breast cancer
. A histochemical method for the detection of steroid‐binding sites in very small tissue specimens was evaluated. Competitive binding experiments proved the method to be sufficiently specific. When applied to endometrium and endometriotic tissue obtained simultaneously from the same patient, a distinct binding was found both in the epithelial structures and in the stroma. The binding pattern in endometriotic glands resembled that in the endometrium. The study seems thus to support the conclusion that endometriotic lesions contain specific binding sites for estrogen and progesterone and that their distribution seems to be similar to that found in the endometrium from the same patient.