Open AccessCytomegalovirus (CMV) and Rubella Virus Infection During Pregnancy
Author(s) -
Haukenes G.,
Finne P. H.,
Bertnes E.,
Ørstavik I.,
Tjøtta E.,
Haneberg B.,
Aarseth P.
Publication year - 1984
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348409156698
Subject(s) - seroconversion , medicine , serology , rubella , cytomegalovirus , pregnancy , rubella virus , titer , immunology , antibody , virology , human cytomegalovirus , viral disease , obstetrics , virus , herpesviridae , vaccination , biology , measles , genetics
. Two blood samples, one in the first and one in the third trimester, were collected from 2014 pregnant women. Serological tests for CMV and rubella antibodies were performed in the paired samples. Seroconversion by the CF test for CMV antibodies was demonstrated in 15 women. However, seroconversion also by the IF test was found in only one of these. A rise in titer during pregnancy by the CF test was found in 16 woman. None of these specimens contained specific IgM. High CMV‐CF antibody titer (>128) in the first serum sample was found in 28 women, but none of the sera contained specific IgM. It is concluded that no single serological test can serve at present as a screening test for the diagnosis of CMV infection during pregnancy. In children thought to be at risk contracting congenital CMV infection, no case with CNS malfunction that could be attributed to a congenital CMV infection could be demonstrated at the age of 7‐8 years. One case of seroconversion in the examination for rubella antibodies was found. The infant of this mother showed no clinical signs of rubella infection.