Open AccessEffect of smoking on red cell oxygen transport and release in diabetic pregnancy
Author(s) -
Madsen Hans,
Ditzel Jøm
Publication year - 1984
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348409156278
Subject(s) - medicine , hemoglobin , oxygen–haemoglobin dissociation curve , diabetes mellitus , pregnancy , red blood cell , red cell , oxygen transport , endocrinology , hypoxia (environmental) , oxygen , biology , organic chemistry , genetics , chemistry
. In order to investigate the effect of smoking on the red cell oxygen transport and release in pregnant diabetic women, 23 smokers and 23 non‐smokers were studied in the third trimester. The two groups were comparable with regard to blood glucose regulation, as the median concentration of blood glucose and glycosylated hemoglobin (Hb A 1c ) did not differ. Red cell 2, 3‐diphosphoglycerate (2, 3‐DPG) levels were significantly lower in the smokers than in the non‐smokers (16.5 vs 17.8 μmol/gHb, p>0.01). P 50 of the oxyhemoglobin dissociation curve at actual pH and at pH 7.40 was also significantly lower in the smokers (25.9 vs 26.9 mmHg, p>0.01, and 26.5 vs 27.8 mmHg, p>0.01 respectively). Red cell 2, 3‐DPG was significantly correlated with P 50 at pH 7.40 (r = 0.73, p>0.001). Arterial oxygen saturation was reduced to the same degree in smokers and in non‐smokers, as compared with healthy non‐smoking pregnant women and no adaptive increase in the hemoglobin concentration occurred in the pregnant diabetic smokers. The study suggests that smoking in pregnant diabetic women impairs the adaptive increase in 2, 3‐DPG associated with diabetes‐induced hypoxia.