Open AccessGrowth and Function of Human Placenta and Amnion Grafted to Nude Mice
Author(s) -
Boltenberg A.,
Furgyik S.,
Kullander S.,
Rausing A.,
Seppälä M.,
Wahlsträm T.
Publication year - 1984
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348409155549
Subject(s) - amnion , medicine , placenta , human placenta , placenta diseases , function (biology) , obstetrics , andrology , pregnancy , gynecology , fetus , microbiology and biotechnology , biology , genetics
. Normal human placenta and amnion from the 20th week of pregnancy were transplanted into nude mice. The transplants retained the histological and immunohistochemical picture of the original tissue and maintained synthesis of human chorionic gonadotropin (hCG), pregnancyspecificβ 1 glycoprotein (SP1), GnRH and placental proteins PP5, PP11 and PP12 for 5 weeks. This experimental model has a wide potential application for studies on placental protein synthesis and the hormonal influence of human placenta on other simultaneously transplanted human tissues.