Open AccessTreatment and Prognosis of met Astatic Gestational Trophoblastic Disease
Author(s) -
Punn R.,
Hori A.,
Okawada M.,
Kudoh R.
Publication year - 1984
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348409155520
Subject(s) - medicine , gestational trophoblastic disease , methotrexate , cyclophosphamide , chemotherapy , choriocarcinoma , craniotomy , surgery , metastasis , hysterectomy , chorioepithelioma , regimen , vinblastine , thoracotomy , pregnancy , gestation , cancer , genetics , biology
. Three cases with metastasized choriocarcinoma are reported. The basic chemotherapeutic regimen was methotrexate and actinomycin D, combined with cyclo‐phosphamide or vinblastine. Surgery was used in the treatment of both primary and metastatic lesions. The chief indications for hysterectomy arise when chemotherapy has obviously failed. Thoracotomy was performed for a pulmonary metastasis and nephrectomy for a metastasis of the kidney. Craniotomy was performed to control the brain hemorrhage. Aggressive multidrug chemotherapy is considered necessary as the primary treatment for high‐risk cases of trophoblastic disease.