Open AccessMaternal‐Fetal Transfer of Aminophylline
Author(s) -
Ron M.,
HochnerCelnikier D.,
Menczel J.,
Palti Z.,
Kidroni G.
Publication year - 1984
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348409155499
Subject(s) - aminophylline , medicine , amniotic fluid , anesthesia , caffeine , fetus , theophylline , gestational age , pregnancy , obstetrics , biology , genetics
. Ten women with normal pregnancies who underwent an elective cesarean section received orally 200 mg of aminophylline every 6 hours for 24—36 hours prior to surgery. The levels of aminophylline and caffeine were measured in maternal and cord sera and in amniotic fluids. The mean level of aminophylline (± SD) in maternal serum was 10.4 ± 1.74 μg/ml, and in cord serum 11.2 ± 1.25 μg/ml. The mean aminophylline level in amniotic fluids was 8.2 ± 1.42 μg/ml. The serum aminophylline levels were within the therapeutic level range. Caffeine levels in those specimens ranged between traces to 6μg/ml which correspond to the normal dietary range.