Open AccessControlled Study of Bromocriptine and Placebo for Induction of Ovulation in Normoprolactinemic Secondary Amenorrhea
Author(s) -
Espersen Thorkild,
Thomsen Anders C.
Publication year - 1984
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348409154670
Subject(s) - bromocriptine , medicine , ovulation , placebo , amenorrhea , hypogonadotropic hypogonadism , endocrinology , ovulation induction , gynecology , hormone , prolactin , pregnancy , alternative medicine , pathology , biology , genetics
. In order to evaluate the effect of bromocriptine in the treatment of secondary amenorrhea, a double‐blind placebo‐controlled study including 30 women with normo‐prolactinemic normo‐hypogonadotropic hypogonadism was carried out. The patients were given either 5 mg bromocriptine or placebo every day for 12 weeks and observed during the following 3 months. A biphasic basal body temperature curve and serum progesterone levels exceeding 25 nmol/1 during the expected midluteal phase were considered an indication of ovulation. Restoration of ovulation was observed in 2 of 17 women given bromocriptine and 4 of 13 women given placebo. Bromocriptine was found to have no specific effect on the restoration of ovulation in women with secondary amenorrhea and normoprolactinemic normo‐hypogonadotropic hypogonadism.