Open AccessFetal Renal Maturation: Studies on urinary beta 2 microglobulin the the neonate
Author(s) -
Takieddine Fayez,
Tabbara May,
Hall Philip,
Sokol Robert J.,
King Katherine C.
Publication year - 1983
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348309156228
Subject(s) - gestation , medicine , amniotic fluid , beta 2 microglobulin , urinary system , fetus , urine , gestational age , creatinine , renal function , endocrinology , pregnancy , biology , genetics
. Beta 2 microglobulin [B 2 m] and creatinine [Cr] concentrations were measure in the urine of 27 newborn infants. At birth, urinary [B 2 m] and [B 2 m]/[Cr] ratios were significantly lower in infants born beyond 36 weeks' gestation. Serial measurements, postnatally, showed a progressive decrease in the urine [B 2 m]/[Cr] ratio of infants born prematurely. These findings suggest an increase in tubular uptake of B 2 m with increasing gestational and postnatal age. The current findings tend to support the hypothesis that the decrease in [B 2 m] observed in amniotic fluid beginning at approximately 36 weeks' gestation reflects maturation of fetal proximal renal tubular function.