Open AccessLevels of Ampicillin and Doxycycline in Human Oviduct Mucosa and Serum
Author(s) -
Brihmer Christina,
Brundin Jan
Publication year - 1983
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348309155797
Subject(s) - doxycycline , salpingitis , oviduct , neisseria gonorrhoeae , ampicillin , chlamydia trachomatis , antibiotics , medicine , gonorrhea , microbiology and biotechnology , gynecology , immunology , biology , human immunodeficiency virus (hiv)
. A common treatment for salpingitis today includes ampicillin (AMPI) and doxycycline (DC), the former against Neisseria gonorrhoeae and the latter against Chla‐mydia trachomatis . The concentrations of doxycycline in oviduct mucosa were found about equal to that of serum and well above the minimum inhibitory concentrations (MIC's) for the bacteriae in question. The concentration of AMPI in the oviduct mucosa was only about 1/40 of that in serum, i.e. 1/10 of the MIC, which jeopardizes the effectivi‐ty of AMPI in the treatment of salpingitis.