Open AccessEndometrial Response Following Percutaneous Estrogen Replacement Therapy
Author(s) -
Cajander Stefan,
Hoist Juhani,
Carlström Kjell,
Damber MatsGöran,
Schoultz Bo
Publication year - 1983
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348309155771
Subject(s) - medicine , estrogen , estrogen replacement therapy , estrogen therapy , hormone replacement therapy (female to male) , uterus , percutaneous , endometrium , endocrinology , urology , gynecology , testosterone (patch)
. The endometrial response in 10 postmenopausal women receiving estrogen replacement therapy was evaluated morphologically and quantified by morphometric analysis. During 6 months of cyclic treatment with percutaneous estradiol‐17β, 3 mg daily, the mean relative endometrial gland volume increased from 10% to 40%. In each individual woman this morphometric parameter was significantly correlated to the serum concentration of estradiol‐17β. The decline in FSH level during treatment showed no significant correlation to the endometrial response or the estrogen level. In some endometrial samples from women during treatment, glands with incomplete epithelial lining and rows of glandular epithelial cells were observed. It is suggested that these phenomena represent early forms of glandular development.