Open AccessTermination of second‐trimester pregnancy by laminaria and intramuscular injections of 15‐methyl PGF 2α or 16‐phenoxy‐ω‐17, 18, 19, 20‐tetranor PGE 2 methyl sulfonylamide
Author(s) -
Bygdeman M.,
Christensen N. J.
Publication year - 1983
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348309154232
Subject(s) - laminaria , medicine , pregnancy , saline , second trimester , intramuscular injection , cervical canal , products of conception , abortion , obstetrics , anesthesia , cervix , surgery , gestation , ecology , genetics , algae , biology , cancer
. The present study included 120 second‐trimester patients admitted to the hospital for termination of pregnancy. In all patients, one medium‐size laminaria tent was introduced into the cervical canal. The laminaria was withdrawn 12 hours later and the patients randomly allocated to either i.m. injection of 15‐methyl PGF 2α , 0.25 mg every second hour, or 16‐phenoxy‐ω‐17,18,19,20‐tetranor PGE 2 methyl sulfonyl‐amide, 0.5 mg every fourth hour. Both treatment scedules were equally effective. All patients but 2 (98.3%), one in each group, aborted within 24 hours of pro‐staglandin treatment. Both methods seem far more effective than other methods at present in use for termination of second‐trimester pregnancy. With the E analogue, the frequency of gastro‐intestinal side effects was significantly lower than with the F analogue and not more common than following hypertonic saline. The use of laminaria tent was normally uneventful and seemed to reduce the risk of cervical laceration significantly.