Open AccessMetabolism of Estrone Sulfate in Human Endometrium
Author(s) -
Carlström K.,
Uexküll A.K.,
Einhorn N.,
Fredricsson B.,
Lunell N.O.,
Sundelin P.
Publication year - 1983
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348309154229
Subject(s) - estrone , estrone sulfate , endometrium , medicine , endocrinology , estrogen , sulfate , metabolism , endometrial cancer , hormone , chemistry , cancer , organic chemistry
. The metabolism of [ 3 H] estrone sulfate was studied in endometrial tissue obtained from postmenopausal women with atrophic endometrium (I), benign endometrial proliferative changes (II) and endometrial carcinoma (III) and in perimenopausal women with proliferative (IV) and secretory (V) endometrium. Total hydrolysis (i.e. formation of [ 3 H] estrone+ [ 3 H] estradiol‐17β) of [ 3 H] estrone sulfate as well as formation of [ 3 H] estradiol‐17β only was significantly less in group I than in the other groups. The formation of [ 3 H] estradiol‐17β was greater in group V than in the other groups. It is speculated that formation of estradiol‐17β in the endometrium from estrone sulfate may be of importance in the genesis of endometrial disorders in the postmenopausal woman.