Open AccessLow LH (Hcg) Receptor Concentration in Ovarian Follicles in Endometriosis
Author(s) -
Kauppila Antti,
Rajaniemi Hannu,
Rönnberg Lars
Publication year - 1982
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348209156957
Subject(s) - endometriosis , receptor , medicine , endocrinology , ovary , ovarian follicle , mechanism of action , andrology , biology , in vitro , biochemistry
. The concentration of LH (hCG) receptors in the granulosa cells of ovarian follicles was assayed in 20 patients with histologically proven endometriosis and in 6 control patients. The levels of receptors in 15 patients with ovarian endometriosis (0.48±0.46 fmol/mg protein) and in 5 patients with endometriosis without ovarian involvement (0.51±0.52 fmol/mg protein) were lower (p<0.01 and p<0.05, respectively) than in control patients (1.32<0.61 fmol/mg protein). The severity of the disease was not reflected in the results. The low receptor concentration in endometriosis suggests a failure in the mechanism mediating LH action in the follicle.