Open AccessPenetration of lymecycline (tetracycline) into the tissues of the fallopian tube
Author(s) -
Bergholm A.M.,
Holm S. E.,
Wiklund D.E.
Publication year - 1982
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348209156951
Subject(s) - fallopian tube , salpingitis , medicine , tetracycline , gynecology , penetration (warfare) , hysterectomy , andrology , surgery , antibiotics , microbiology and biotechnology , biology , operations research , engineering
. On the basis of a comparison of different methods used to determine the concentration of active lymecycline in Fallopian tube tissue, a method was adopted which allowed the determination of lymecycline in serosa and mucosa tissue of the Fallopian tube in 16 women undergoing hysterectomy. A difference in the concentration of active drug was found in serosa (>1.7 mg/kg tissue) and mucosa (>0.8 mg/kg tissue) in 16 patients on lymecycline therapy for 24 hours. These figures were fairly constant for the 7.5 hours following the administration. The figures are discussed in relation to the MIC values of the commonly found microorganisms in salpingitis.