Open Accessα 2 ‐Antiplasmin and α 2 ‐Macroglobulin—The main inhibitors of fibrinolysis—During the Menstrual Cycle, Pregnancy, Delivery, and Treatment with oral contraceptives
Author(s) -
Wallmo L.,
Gyzander E.,
Karlsson K.,
Lindstedt G.,
Radberg T.,
TegerNilsson A. C.
Publication year - 1982
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348209156583
Subject(s) - medicine , pregnancy , menstruation , luteal phase , menstrual cycle , fibrinolysis , pill , endocrinology , alpha (finance) , progestogen , endocrine system , physiology , hormone , pharmacology , genetics , biology , construct validity , nursing , patient satisfaction
. α 2 ‐Antiplasmin and α 2 ‐macroglobulin have been studied during the menstrual cycle, pregnancy and parturition in healthy women, and during use of various types of contraception in both healthy and diabetic women, and compared with a reference group of healthy men and women. α 2 ‐Antiplasmin showed a slight sex difference, with higher values in women. The luteal phase of the menstrual cycle showed slightly higher values than the other phases. α 2 ‐Antiplasmin increased during pregnancy, decreased (probably due to consumption) during labor and increased again in the puerperium. Treatment with neither combined contraceptive pills nor low dose progestogen pills gave any changes in α 2 ‐antiplasmin. α 2 ‐Macroglobulin showed low values during menstruation. The increase during pregnancy and treatment with combined contraceptive pills is in accordance with earlier findings. It is concluded that synthesis and metabolism of α 2 ‐antiplasmin are under hormonal influence. The role of α 2 ‐antiplasmin in the decreased fibrinolysis in pregnancy is discussed.