Open AccessMetronidazole Prophylaxis in Abdominal Hysterectomy
Author(s) -
Manthorpe T.,
Justesen T.
Publication year - 1982
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348209156565
Subject(s) - medicine , metronidazole , placebo , abdominal hysterectomy , hysterectomy , anaerobic exercise , surgery , placebo group , randomized controlled trial , anesthesia , antibiotics , physiology , alternative medicine , pathology , microbiology and biotechnology , biology
. The use of prophylactic metronidazole in elective total abdominal hysterectomy was evaluated in a prospective, double‐blind randomized study. The rate of complicated wound healing was 18% in the metronidazole group and 13% in the placebo group. The bacteriologically confirmed wound infection rate was 3.9% in both the metronidazole and the placebo group. Only one of the infections was anaerobic and it appeared in the placebo group. No pelvic infections were observed in either of the groups and hospital stay was the same in both. Peroperative investigations of the vaginal flora showed significantly fewer anaerobic strains in the metronidazole group than in the placebo group.