Open AccessEffect of Prostaglandin E 2 and F 2α on the Systemic and Pulmonary Circulation in Pregnant Anesthetized Women
Author(s) -
Secher N. J.,
Thayssen P.,
Arnsbo P.,
Olsen J.
Publication year - 1982
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348209156559
Subject(s) - medicine , systemic circulation , circulation (fluid dynamics) , prostaglandin , prostaglandin e , pregnancy , prostaglandin f , anesthesia , obstetrics , physics , biology , genetics , thermodynamics
Abstract. The hemodynamic effect of prostaglandin F 2α (PGF 2α ) and of prostaglandin E 2 (PGE 2 ) was studied in 12 healthy volunteers admitted for suction abortion at 10–12 weeks of gestation. They were anesthetized using natrium thiomebumal, pethidine and pancuronium bromide. PGF 2α was given as an intravenous infusion of 100 μg/min, the dose being increased by 100 μg every 10 min to a maximum of 300 μg/min. PGE 2 was administered with 5 μg/min, the dose being increased by 5 μg every 10 min to a maximum of 15 μg/min. During infusion of 300 μg PGF 2α a significant increase in cardiac output and femoral arterial pressure of 40% and 25% respectively was measured together with an increase in the pulmonary arterial pressure (125%). Pulmonary vascular resistance was doubled, with a concomitant decrease in systemic resistance (11%). These changes were followed by a significant decrease in pH and PaO 2 , whereas an increase in PaCO 2 was found. During infusion of PGE 2 a significant, 36% increase in cardiac output was measured during infusion of 15 μg/min PGE 2 , together with a decrease in systemic blood pressure (31%) and resistance (33%). Heart rate rose significantly, while stroke volume showed only a small increase, and pulmonary pressure was unchanged. These changes were followed by an increase in PaO 2 . PGF 2α seems to have a positive inotropic effect on the heart, whereas its response to PGE 2 seems to be a result of the peripheral vasodilatation. The slight decrease in systemic blood pressure without change in pulmonary hemodynamics makes PGE 2 suitable for induction in patients with cardiopulmonary diseases.