Open AccessLevels of Trimethoprim and Sulfamethoxazole in Human Oviduct Mucosa and Plasma
Author(s) -
Brihmer Christina,
Brundin Jan,
Dornbusch Katrin
Publication year - 1982
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348209156546
Subject(s) - microgram , medicine , trimethoprim , oviduct , agar , sulfamethoxazole , chromatography , plasma levels , pharmacology , microbiology and biotechnology , antibiotics , chemistry , in vitro , biochemistry , biology , bacteria , genetics
. The oviductal and plasma levels of trimethoprim (TMP) and sulfamethoxazole (SMZ) were studied in 9 women after oral and i.v. administration of a drug combination (Eusaprim R , Wellcome Foundation Ltd.). The concentration of TMP in a healthy endosalpinx was found to be twice as high (4.7 μg/g, range 2.8–8.3) as in plasma (2.6 μg/ml, range 2.1–3.6). Conversely, the endosalpingeal level of SMZ (38 μg/g, range 12–65) was about half that in plasma (77 μg/ml, range 58–95). The agar well diffusion method was used for the concentration determinations. The specimens were collected during surgery for non‐infectious genital diseases. The implication of treatment by the given drugs is discussed.