Open AccessA Comparative Longitudinal Study on Sex Hormone Binding Globulin Capacity During Estrogen Replacement Therapy
Author(s) -
Helgason S.,
Damber J. E.,
Damber M. G.,
Schoultz B.,
Selstam G.,
Södergård R.
Publication year - 1982
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348209156536
Subject(s) - sex hormone binding globulin , estrone , estriol , estrogen , medicine , endocrinology , globulin , hormone , menopause , androgen
. An aqueous two‐phase equilibrium partition system was used to assay SHBG‐binding capacity. Sera from groups of postmenopausal women before and during unopposed estrogen replacement therapy were analyzed. The induction of SHBG showed considerable differences between different estrogens. Ethinyl‐estradiol in a daily dose of 0.05 mg gave a 70% increase in the serum concentration of this liver derived protein. Estradiol‐17β, 2 mg daily and estrone sulphate 1.25 mg gave moderate changes, whereas estriol in different doses had no effect. SHBG induction may reflect estrogen overtreatment.