Open AccessRoutine Liver Function Testing During Long Term Administration of the Oral Contraceptive Preparation 0.150 Mg Desogestrel Plus 0.030 Mg Ethinylestradiol to Healthy Female Volunteers in Scandinavia
Author(s) -
Odlind Viveca,
Borglin Nils Erik,
Christensen Ole J. E.,
Cullberg Göran,
Enger Lennart,
Fjárestad Ingemar,
Klottrup Paul,
Sandager Torben,
Secher Kirsten
Publication year - 1982
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348209155358
Subject(s) - medicine , desogestrel , ethinylestradiol , liver function , liver function tests , pill , alkaline phosphatase , endocrinology , oral administration , bilirubin , physiology , pharmacology , population , family planning , research methodology , biochemistry , environmental health , enzyme , chemistry
. During administration of an oral contraceptive pill containing 0.150 mg desogestrel and 0.030 mg ethinyles‐tradiol, routine liver function tests were performed before and after 3, 6, and 12 months of treatment. No significant changes in serum amino aspartate transferase or serum alanine amino transferase were recorded during treatment. The serum alkaline phosphatase level decreased significantly after 3 and 6 months and then returned to normal. No changes in serum bilirubin were found. Briefly, no significant changes in the liver function tests were found, indicating no impairment of the liver function throughout the medication period.