Open AccessEffects of Estrogen Deficiency in Women Castrated When Young
Author(s) -
Svanberg Lars
Publication year - 1982
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348209155324
Subject(s) - medicine , castration , estrogen , oophorectomy , osteoporosis , incidence (geometry) , salpingitis , endocrine system , physiology , hormone , menopause , endocrinology , gynecology , hysterectomy , surgery , physics , optics
. In earlier studies on the effects of castration, most of the women had been operated on late in the reproductive period of life. In the present material all the 142 women had been oophorectomized between the ages of 15 and 30 years because of advanced salpingitis. Not only the tubes but also the ovaries had been radically removed. The series was analyzed in respect of causes of death, survival, morbidity, osteoporosis and hormonal state. Complete oophorectomy was found to be followed by (i) a significant increase in the frequency of coronary heart diseases; (ii) an increase in serum cholesterol and triglyceride levels, most significantly in those aged below 60–65 years; (iii) an increased incidence of fractures; (iv) an increased frequency of nervous disorders of psychological rather than endocrinological origin.