Open AccessProgestogen Effects and their Relationship to Lipoprotein Changes
Author(s) -
Wingrave Sally J.
Publication year - 1982
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348209155315
Subject(s) - progestogen , medicine , pill , incidence (geometry) , estrogen , bloodletting , family planning , disease , physiology , obstetrics , gynecology , endocrinology , population , research methodology , pharmacology , alternative medicine , environmental health , pathology , physics , optics
. The Oral Contraception Study of the Royal College of General Practitioners is a long‐term, controlled, prospective survey which is now in its 14th year. The substantial data accumulated permits assessment of the effects of particular brands upon morbidity. We have shown that the progestogen content of the Pill is associated with the incidence of hypertension, benign breast disease and, more important, of total arterial disease. The data support the findings of other investigators who have shown that progestogens lower HDL‐cholesterol levels and that low HDL‐cholesterol increases the risk of arterial disease. The implications are that the progestogen content of an oral contraceptive and the relative potency of the estrogen and progestogen it contains must be considered carefully not only in terms of present clinical practice, but also in terms of the direction of new Pill formulation development.