Open AccessGLUCOSE TOLERANCE FOLLOWING ORAL SALBUTAMOL TREATMENT IN LATE PREGNANCY
Author(s) -
Wager J.,
Lunell N. O.,
Nadal M.,
Östman J.
Publication year - 1981
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348109158133
Subject(s) - salbutamol , medicine , pregnancy , carbohydrate metabolism , oral administration , glucose tolerance test , insulin , endocrinology , anesthesia , insulin resistance , asthma , genetics , biology
. Previous studies in pregnancy have shown that in‐travenous infusion of beta‐sympathomimetic drugs, such as salbutamol, is followed by pronounced carbohydrate and lipid metabolic effects. Similar effects, though less pro‐nounced, have also been demonstrated after oral salbutamol administration. Glucose elimination and insulin response after an intravenous glucose tolerance test (IVGTT) were analyzed in 12 women treated with oral salbutamol in the last trimester of pregnancy. IVGTT was performed without salbutamol and after at least 10 and up to 45 days of salbutamol treatment. No significant difference in either glucose elimination or insulin response to the glucose load were observed as a consequence of the salbutamol medication. This is in agreement with previous studies of other beta2‐sympathomimetic drugs and indicates that the use of salbutamol in late pregnancy does not give rise to serious disturbances of carbohydrate metabolism in healthy women.