Open AccessIN VIVO LOCALIZATION AND TURNOVER OF RADIO‐IODINATED HCG IN WOMEN WITH MYOMAS AND IN NUDE MICE WITH OVARIAN TUMOR HETEROGRAFTS
Author(s) -
Carlsson Sten,
Kullander Stig
Publication year - 1981
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348109158132
Subject(s) - ovary , in vivo , corpus luteum , medicine , endocrinology , ovarian tumor , antral follicle , ovarian cancer , biology , cancer , microbiology and biotechnology
. Specific localization in vivo of marked, 131 I‐labelled human chorionic gonadotrophin (HCG) was shown by scintillation counting of different tissues to occur in rat ovarian tumor, but not in human Krukenberg tumor hetero‐grafts growing subcutaneously in female nude mice. The ovaries of the mice showed an increased uptake. This model system may be useful for studying gonadotrophin receptors and gonadotrophin dependency of human ovarian tumors. A similar study in menstruating women about to be operated upon because of myoma showed a remarkably high uptake in the corpus luteum, but binding also in ovarian follicles. The increased uptake of the radioactivity observed in the ovaries enabled preliminary scanning. This unique specificity of uptake may offer new possibilities in the diagnosis of ovarian tumors. The general turnover of the 131 I‐HCG in these women is described and applied to a mathematical model. High relative concentrations of 131 I were also seen in urine and saliva.